I don't think a bad salvia trip is as serious as a bad trip on shrooms or LSD, mostly because the salvia trip just doens't last long enough. If you use a responsible amount of salvia, the worst that could happen is you'll get freaked out for a few minutes and then feel unpleasant for a while. You may find the experience disagreeable and not want to do it again, but it shouldn't do any permanent damage. I've only used 10x and 15x, though. I can't say anything about higher doses.