I wouldn't smoke it stoned for the first time-- you sorta have to get to know the drug a bit, as it tends to be a rather intense experience.

However, once you've done it once or twice, you should be ready. Doing it while already high is a really intense experience. I tend to get paranoid from weed, but once I knew approximately what kind of reaction to expect from salvia, I didn't freak out.

The real trick is just to not fight the trip; roll with it, and everything's great.