Vioxx (rofecoxib) is a nonsteriodal anti-inflammatory drug. It is the same class of drug as Ibuprofen and has about the same recreational value (none). Rofecoxib selectively inhibits the COX-2 enzyme responsible for the production of prostaglandins which seem to play a role in pain and inflammation.

Opioids such as hydrocodone and oxycodone are much different. These drugs work by binding to opioid receptors in the brain, the consequence is euphoria and feelings of warm fuzzyness.