i would not reccomend trying it. the drug is not designed to be flammable, so i imagine that if you did it the most you would get would be a bad headache. you could snort it too, but from what i hear it hurts alot. even if you did manage to gain some positive effects from smoking it, i cannot imagine they would be as strong as if you took it orally. if your wondering if it will change your high, take the vicodin before and then smoke pot while your high on vicodin.