nowhere near the same. with benedryl, your head remains in this dimension while datura takes you someplace else, and never a friendly place. it'll turn your world a yellowish tinge which can last for weeks, sometimes far longer. large doses can destroy your liver and kidneys while some never recover mentally. your mouth will be like someone stuck a sponge filled with cotton balls which are filled with sand soaked in some god-awful stuff that is hard to descibe...i'd say the left-over flavor is like peyote (without the peyote experience) mixed with cat shit. if you're still excited about the stuff, crush no more than 10 seeds then boil in water for 15-20 minutes (have a ton of sugar handy too) and have a sober friend who's not afraid to rush you to the hospital standing by...sounds like fun, eh?