Lexapro (the single-isomer of Celexa) has worked wonders for me. My doc told me that if you dont have a serotonin imbalance, then anti-depressants will not do anything for you. I must have had a serious imbalance because I definitely noticed a huge difference within the 1st week, more than I ever expected from the medication. And I certainly wasn't expecting to get high as that is not the point of the medication.

The only negative side effect Ive had is lethargy. Initially it was pretty annoying, but now its not as bad. Its a side-effect Im willing to live with given the positives Ive experienced from this medication.