The quality of the bud you get effects it for sure, if your smoking dank and one day you run out and are forced to smoke some schwaggity I tend to get sick to my stomach =S or vice versa if your accustomed to low grade and you smoke some bomb diggity it can DEFINITELY make you puke. I dont know where you live or what its like but around here (mostly LA or the ghetto parts of riverside) you will find lots of sketchy fucks who dont have a problem dippin your buds in some PCP or somethin else just to fuck with you. Ive seen a kid cryin in a corner tryin to slit his wrists cuz he bought some bunk shit laced with embalming fluid. Main lesson - dont smoke what you dont know