seratonin is chemical in brain which creates endorphins. it makes you happy. alot of e use can deplete your seratonin. it depends on hoe much u use and how often. alot of times e isn't always e as well. if you do a hell of alot it cvan also permanently danmage your seratonin receptors meaning your brain will no longer be capable of storing it (ie. not releasing ti immediately) this is very rare however so dont worry about it too much. what e forces your brain to do is release a whole bunch of seratonin at once (maybe all depending on how much you take and how much seratonin you have, you will have less if you use e very often) If you don't do e too often, you'll be fine. ialso recommend taking a whole bunch of vitamin c the day after as much as you can take. cause that will up your seratonin sometimes to even higher levels than when before you took the e therefor preventing a bad come down. come downs can last a long time if it puts you in a depressed state cause when your mind becomes depressed it tries to not release very much seratonin at all because it thinks it doesn't have enough. this can tak a long time before it starts to function normally again. your body doesn't usually become like this untill after you start using very regularily. once a month is perfect your body has enough time to recover and you will have no dangerous complicatioins but you may not want to wait that long. in this case i recommend you stick to a rule of absolutely no more than once a week.