Most I've taken at once = 5 hits blotter. Usual dosage = 2. If you know how strong the hits are you can get a pretty good idea of how many you might want to take. Not much of a science to it as batches of acid vary in potency as can some hits within each sheet. Although I personally have never gotten a super-strong hit out of a sheet of regular stuff. The more comfortable you are, the more time you have, the more you can take. If you have only done 1 hit before, try two next time you have the right time and situation. Weed can be used after your peak to help with jitters and to kick the fun back in. Nitrous can be done if you want to see some shit, like your friends as cartoon figures.