i can't say in exact hours how long but it is gone from your system in less than 24 hours..it is like any other liquid.....it is abosorbed to your body and filtered out via. liver and intestinal tracts....me myself have a very high tolerance to any and all medication (in pill form, iv's or liquid work just normal on me) and used to drink all the time while on MULTIPLE anti-depressants (i know it's unusual for any one doctor to prescribe more than one, and my even be unbelievable for some) but i am a poster child for a multitude of mental illnesses and the doctor believed (and it did help while i was on them) that i needed multiple ones.....IMO it all boils down to your body, chemical make up and your body's way of dealing with certain things...but since i'm not a scientist and can't tell you certain things to look for and what not.....i can't really tell you but to experiment on your own AT EXTREMELY LOW DOSES at first AND AT YOUR OWN RISK....although i really wouldn't suggest it becasue there is the probabillity of very adverse side effects to it .....