Quote Originally Posted by Zero Revolt
And that's a fact!
Um, no, it isn't. First of all there's no such thing as a "lethal dose" of any substance. The best we can do is state at what dosage fatality occurs in such-and-such a percentage. The de facto standard is the dosage lethal to 50% of the population, listed as LD50 on MSDS sheets. Secondly, we have no idea exactly what the LD50 for marijuana in humans is. We have data for rats and mice, which typically call the LD50 for THC as being greater than 600 mg of THC per kg of body weight. I did some math. If we apply this to an average human, it means he would need to ingest 54,545 mg of THC to have a 50% chance of dying from it, if he weighs 200 pounds (91 kg). Really good weed has up to 24% THC content, by weight, which means you'd have to smoke 227 grams of high-quality weed to get that much THC. That's quite a lot - far more than any normal person could smoke in one sitting - but nothing near as high (ha!) as the figures being quoted here. However, it's important to note that we can't apply these figures to smoking in humans, in any case. The rat LD50 figures are only valid for an oral dose of pure THC and only accurately apply to rats. The figure may be significantly different for a human smoker - we just don't know. Nevertheless, it is reasonably safe to say that no human being can smoke enough weed to die from THC toxicity alone.