Can you OD on weed?

[Zero Revolt]

Um that's a negative on overdosing on weed. From a proven scientific perspective it would take 40,000 times the amount of one blunt to kill a human being. And that's a fact!

[Beeblebrox.420]

And that's a fact!

Um, no, it isn't. First of all there's no such thing as a "lethal dose" of any substance. The best we can do is state at what dosage fatality occurs in such-and-such a percentage. The de facto standard is the dosage lethal to 50% of the population, listed as LD50 on MSDS sheets. Secondly, we have no idea exactly what the LD50 for marijuana in humans is. We have data for rats and mice, which typically call the LD50 for THC as being greater than 600 mg of THC per kg of body weight. I did some math. If we apply this to an average human, it means he would need to ingest 54,545 mg of THC to have a 50% chance of dying from it, if he weighs 200 pounds (91 kg). Really good weed has up to 24% THC content, by weight, which means you'd have to smoke 227 grams of high-quality weed to get that much THC. That's quite a lot - far more than any normal person could smoke in one sitting - but nothing near as high (ha!) as the figures being quoted here. However, it's important to note that we can't apply these figures to smoking in humans, in any case. The rat LD50 figures are only valid for an oral dose of pure THC and only accurately apply to rats. The figure may be significantly different for a human smoker - we just don't know. Nevertheless, it is reasonably safe to say that no human being can smoke enough weed to die from THC toxicity alone.

[mono repin]

Careful beeblebrox, even with your 227 gram figure, you have neglectected time period. From the second thc hits your bloodstream, some of it is being processed and disposed of. So with that in mind, you must smoke x grams in x amount of time. Also, your assuming all thc goes to the user, which would indicate vaporization, which from what I've heard doesn't lend well to MASSIVE quantities of weed, as you just get too stoned from a little to make larger quantities worth while. Also keep in mind, smoking or orally injesting the weed, rats will only give us a rough idea about the human tolerance. There maybe some unkown factor making humans several times more or less vunlerable to OD. However, it is VERY clear, that OD'ing is for all practical purposes impossible, unless you were really trying.

[BUZz UK]

I did some math.

no, you did some MATHS

[Beeblebrox.420]

Careful beeblebrox, even with your 227 gram figure, you have neglectected time period. From the second thc hits your bloodstream, some of it is being processed and disposed of.

Yes, which is why I said "in one sitting".

Also, your assuming all thc goes to the user, which would indicate vaporization, which from what I've heard doesn't lend well to MASSIVE quantities of weed, as you just get too stoned from a little to make larger quantities worth while.

Right, but we have to make that assumption, in order to get a decent first-order approximation of a worst-case scenario. My point was to show that a lethal dosage of THC is a practical impossibility even under ideal conditions, let alone real-world ones.

Also keep in mind, smoking or orally injesting the weed, rats will only give us a rough idea about the human tolerance. There maybe some unkown factor making humans several times more or less vunlerable to OD.

Umm, yes, I said that. In fact, I was very clear on that point. See:

However, it's important to note that we can't apply these figures to smoking in humans, in any case. The rat LD50 figures are only valid for an oral dose of pure THC and only accurately apply to rats. The figure may be significantly different for a human smoker - we just don't know.

[Beeblebrox.420]

no, you did some MATHS

Nah, I only did it once.

[BUZz UK]

hahahaha, love it

[LOVElife]

no, you did some MATHS

That is One thing I hate, haha, I WOULDN'T DARE HAVE CALLED IT MATH WHEN I WAS AT SKOOL, OR NOW, it was always MATHS!! OR BUCKETS AND HOT CANS IN THE GARAGES ND FUCK MATHS!

[BUZz UK]

lol, yeah, i think i indulged in the odd spliff when i was supposed to be in maths....and chemisty, physics, RS, English, french, tech, etc......