Sal. Divinorum will not mess you up if you use it right. 5-Hydroxytrytophan (5-HTP) is a serotonin precursor produced naturally in your body, and converted to serotonin (a key neurotransmitter in suchs things as consciouness, happiness, hunger, and digestion). Take a few bong hits, as many as you can before not being able to hold the bong any more, of some unfortified salvia, give it a few seconds, and the few hour long afterglow will have you smiling wide for a good while, mixed with herb and HTP.

-Cin