I'm diagnosed with recurrent major depression and on meds. My experience is that MJ improves the mood on the day of ingestion (big insight, huh?!) The next day is a little like a very mild hangover but I find my head clears and things seem more in correct proportion. If you have an addictive personality however, you are in danger of becoming psychologically dependent on it which adds to your problems. I smoke only occasionally when I need a lift or a head vacation from my worries.