i usually would take about 5 darvocets, drink something with some caffeine, it seems to increase the absorption...chew em up...i actually used to take excedrin migraine with it if i didn't have but 2 or 3...the caffeine in it helps, but be careful with acetaminophen doses, it won't really hurt you immediately unless you like down a whole bottle...but it can cause long-term liver damage...darvocets can take 2 hours or more to start working...i took them in high school one morning and they didn't hit me until after school that day...so it can take a while...