It takes about an 45 min. to an hour and half to fully kick in. Best way to ease your way into a dxm trip is to just lay down next to your toilet, cause sometimes it makes your stomach feel shitty and you have to go for about an hour on the floor. I just close my eyes and let my mind take me where ever it wants to go, I have surfed the internet while laying on my back in my bathroom before and once I was the main guy from halo shooting all the bad guys it was a blast! well hey Happy Tripping