"The objective of this part of the study was to determine
whether creatine supplementation could increase the amount
of creatinine in human urine specimens even after hyper-hydration. People undergoing mandated drug screening sometimes consume a large volume of water prior to testing in an
attempt to wash away the presence of illicit water-soluble drugs
in the body. The tests showed that over the course of an 8-h period the creatinine concentration declined consistently without
any significant elevation even in participants who took creatine"