Thanks for your reply Mal. She has been taking avonex for about a year now and yes this drug does cause flu like symptoms,although the longer you take this drug the symptoms diminish.Last night was first time she has felt sick in a long time and we were just concerned that the cannabutter was having an adverse reaction to the drug.Our objective is to have proof that cannabis does help with the pain it seems you need iron clad proof before doctors will even entertain the idea of discussing medical marijuana or only prescribe it if your on deaths door .I do not(BECAUSE OF MY JOB) smoke but have in the past my wife has never used weed . I powers do believe in the healing of marijuana but I don't want to cause any harm to my wife she suffers enough.Once again thank you for your help and if anyone else out there has any advice we would greatly appreciate it.