Um. If your basement has a mold problem, making sure your pulling in air from outside. There are some awesome 4x4x8 rooms setup with a single 600/1k HPS that yield 3 pounds per grow with good CO2 systems and awesome nutes. Don't dabble in soil if you can start with DWC. If you have the space and the cash, start with DWC, don't be scared.

If you want to start with a 4x8 that's fine, but use that for flowering and buy a cabinet for your cloning/vegging - You can read my CFL cabinet guide to get a good idea on how to do that, just use DWC instead of soil and you'll be golden. My clones take about 7 days to root in my cubes, with a bubbler they'd be a day or two faster. Also you can fit alot more in a veg cabinet using a 16 site DWC for veg vs my setup which only houses 3 moms

I would also recommend a battery backup system for your DWC's in case of power failure but that's it really - Look at the good guides, there are plenty of them... My cabinet will give you a good 300-500 cabinet and if you switch to dwc cloning/vegging you can get 5x the amount of plants in there that I can!