Yes, but the formulas are different. Make sure you are using a feeding schedual designed for soil.. Im pretty sure the calculator on their website has an option for soil or hydro.. Most plant foods can be used with both, but the mixtures are usually strong with hydro. If you plan on sticking with Advanced.. I highly recommend their B-52, Carboload, Voodoo Juice, and Big Bud.. the additives are quite expensive.. but they work well.. Especially the B-52.. I also recommend foilar feeding with an organic seaweed extract like Growth Plus.. spray every day at lights on.. stop two weeks before harvest.. the stuff works wonders!