the major difference is the high if you ask me, indica is more of a sleepy high, and sativa is more of a energtic high, when i smoke indica i usally just sit back watch tv or something, then eat then im sleep, and when i smoke sativa i usally start cleaning the house or move my room around, basically just look for something to do lol hope i helped
ducthyroller#1 Reviewed by ducthyroller#1 on . Indica-Sativa What are the major differences between Indica and Sativa? Rating: 5