Quote Originally Posted by Weezard
I think the increase in tolerance requires a healthy liver.
Your brother's is the third case I have read that is unable to ramp up the dosage.
All had a compromised liver function.
The good news is, the active ingredients stay in the body at a higher level, for a longer time.
That's why he feels so stoned. Kind of a "cheap drunk" thing.
It should be as effective as a larger dosage is in a person with normal liver function.

At least that's my take on it.
I am NOT a doctor.

Aloha,
Weezard
I don't know the actual health of his liver at this time but what you say does make sense. If the liver is compromised it only seems logical that the active ingredients are not being processed and flushed out effectively. The other challenge may be the oil. All I had was high THC strains available to make the oil with. In January, I will have some CBD Crew 1:1 strains made available to me. Lower THC and higher CBD content. Hopefully these will be much more tolerable and the addition of the high CBD will be more beneficial.

The caps I have been making him have approximately 15.5mg of pure extract reconstituted in coconut oil. This equates to around 1/64gm of extract. At this dosage, he does get stoned but says it's highly tolerable. I made some other caps at 25mg and he said he cannot even watch TV when taking them. I am assuming that continuing even at the smaller doses is better than stopping. I will be making him some more of the lower dose caps until the high CBD materials become available.

On the good side, he does mention that his pain lessens when medicating with the caps. He is able to cut his pain meds in half.