Quote Originally Posted by LordLemon
OK, Day 1: Drank 32 OZ of Gatorade along with 500mg of niacin. Now, I know many claim niacin doesn't work while others say it does. I'm going with the hypothetical that it only helps clean you out. We'll see.
Some like to claim that because it is a vasodilator that having bigger tunnels for blood to flow is tantamount to faster THC metabolite excretion. They are taking an illogical leap that has no basis in fact. Some like to cling to the fact that it speed up ones metabolism. Well so does smoking cigarettes but I don't suggest people do something that could be potentially harmful in the name of trying to get THC out of their system. You can increase your metabolism 100x more by simply doing 15 minutes of fat burning exercise.

In addition, when taken in greater than the daily recommended dose, niacin can wreak havoc on the liver and can lead to liver failure. Just because niacin is involved in fat metabolism does not mean that more equals better/faster or else we would have so many lard asses in this country and niacin would be touted as the weight loss miracle cure. It isn't nor does it do a thing to speed up THC unloading.

Dilution does not require niacin. It requires water (creatine and b2 help).

If you are trying to naturally clean yourself out, then taking the DRD dose of niacin will more than suffice. Fat burning exercise and time is the miracle cure, nothing else.

Until someone shows that niacin has a positive influence on the metabolic pathway involved with hydroxylation of THC, it will continue to just be a myth proliferated by followers of the father of Scientology and L Ron himself.

THC is excreted mostly as hydroxylated and carboxylated metabolites. Rougly 65% is excreted in feces and roughly 20% or so eliminated in the urine. The main urinary metabolite is THC-COOH glucuronide conjugate. The main feces metabolite is 11-OH-THC. The concentration of free THC-COOH and the cross-reactivity of glucuronide bound THC-COOH enable cannabinoid immunoassays to be done directly on the non hydrolyzed urine but confirmation and quantification of THC-COOH is done after alkaline hydrolysis of B-glucuronidase hydrolysis to free THC-COOH for measurement by GC/MS. There are a few good books that are quite in depth about our favorite plant, Cannabinoids in Nature and Medicine is one I have on my desk right now.