Here it's based on patient numbers, not years.

Medical Marijuana Center (Type 1*): $7,500 application fee
Medical Marijuana Center (Type 2*): $12,500 application fee
Medical Marijuana Center (Type 3*): $18,000 application fee
Optional Premises Cultivation License: $1,250
Medical Marijuanaâ??Infused Products Manufacturer: $1,250
*Type 1=300 or fewer patients, all Colorado residents; *Type 2=301 to 500 patients;
*Type 3=501 or more patients.

Most towns have an additional local application fee as well. Denver's, for example, is $5000.