3 weeks into flowering... don't touch them, what a waste, keep them flowering for atleast 4 -5 more weeks.

Buds gain extreme weight within the last 2 weeks of growing this can account for upto 1/4 of your yeild sometimes, you want to harvest when atleast 75% of the hairs have turned orange/brown/red

then don't make the mistake of wasting a grow with silly speed drying or ruining the manicuring.

Patience is a virtue, in this case, one that rewards you kindly.

IF and ONLY IF you feel the need to pluck, and i hope you don't, jus some of the smaler buds around the bottoms of the plants, but the longer you hold out, the bigger the yeild in the end