I am bipolar with anxiety and insomnia and I smoke every day (when the supply allows). I can't say that cannabis has made me any more depressed (like the propoganda would have you believe)... If anything I think it has elevated my mood. I used to take Lithium, Xanax, Trazodone, and Depakote at the same time. Since I started smoking cannabis every day, I no longer take any psychiatric meds.