Hey also found this info on their site.

Simply dip the cutting in your choice of cloning hormone, place cutting in the neoprene collar and place in the two-inch pot.

Botanicare also suggests using a cloning solution and fungicide in the Clone Machine Reservoir.

Operate the machine for 24 hour periods until roots appear (3 to 10 days). Transplant into any desired grow substrate.

Clone Machines work best with 16-24 hours of Fluorescent lighting at eight-inch to twelve-inches. Misting leaves once or twice daily is also helpful or use an optional Humidome available with the 74 and 154 plant cloners.

Clone machine must be sterilized with disinfectant between crops.

Now that sounds pretty easy to me....its nice they include the neoprene caps I am guessing it holds the mist in nicely.