The irony in all this is we take aspirin, which occurs naturally, tribal people in south America would suck on the bark. Obviously we aren't sucking on barks, were taking a synthesized version of aspirin. Human made isn't necessarily a bad thing. It's pure adulterated chemical, without the bullshit isn't that better?

However the problem with man-made drugs, due to the black market can be easily tainted. It's depends on the uniqueness of the chemical reactions that occur when we use something, whether it's smoking marijuana, snorting meth, taking an RC such as 2c-e, datura, etc etc. All that matters is the effects it produces.