I also felt like I might get denied (even though my condition is exceedingly well documented), until I looked up the stats:

(as of July 31, 2009)
Statistics of the registry include:

* 13,102 new patient applications have been received to date since the registry began operating in June 2001. Twenty-nine (29) applications have been denied, 18 cards have been revoked, 210 patients have died, and 1,751 cards have expired, bringing the total number of patients who currently possess valid Registry ID cards to 11,094.

Source: Colorado: Department of Public Health and Environment, Colorado Medical Marijuana Registry