Aspirin was originally derived from willow bark, opium comes from poppies, cocaine is derived from the coca plant, mescaline comes from a button cactus, digitalis was first sourced from foxglove, penicillin grows naturally in certain moulds.
Most of those if not all are derived maybe, but ALL man made into what they are today.

Marihuna is derived and STILL comes from the earth. Nobody adds anything to make it what it is. It is, what it is.