I would grow your plant untrimmed (besides maybe a top pinch for branching) the first time. Then you have an idea of what your genetics do. If you see that the skinny lower branches don't amount to much you may chose to trim them. If you trim them and the plant responds with male flowers you won't know if you have a real hermie or you stressed it into a pollen sac or two.

I suppose it all depends on what you are after. If you only have a couple plants, leave it. If you are so dense with vegetation that things are getting nasty, trim until you have some breathing room.

I mostly trim whatever looks neglected or yellowed/dwarfed/sickly. Unless I have a tight ass scrog going. But in that case you have selected one type of plant for it's scrog-ability and it's probably not going to hermie or stunt due to stress.

Or...just cut it down, microwave it and tell all your pals that it was magical weed that they'll never try...EVER!
That's what I did on my first grow.