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Dutch Pimp Reviewed by Dutch Pimp on . Dose level (of which cannabinoid) needed to shorten R.E.M. duration ? By this point, we have all read/seen/heard this: Madsci.org Article:Re: What are the hamful effects of marijuana? Regardless of how conclusive the study is, let's take it at face value.... ...It states that low doses may produce drowsiness, and high doses may actually shorten the duration of the REM sleep period. I am curious: 1. which of the cannabinoids or constituents in resin glands is/are responsible ? 2. how high of a dose of this/these cannabinoids is needed to produce this Rating: 5