French Tolerance Study 2/09

[Coelho]

But if you were more resistant of the effects of THC, wouldn't you also become more resistant to the impairing effects on memory as well? Like when you first smoke, you feel more burnt-out, but as you smoke more, you feel the effects of the burnout less. Why wouldn't it be the same with memory impairment.

I agree with you, and i think everybody else would too, because it is the most reasonable thing.
But the findings of the study are exactly that, despite of what everybody used to think, there is no build of tolerance for the memory impairment . Probably this unexpected effect was what motivated them to write the article.

I mean I feel like I have a good memory overall and that cannabis hasn't impaired it, only in the short-term when high.

Exactly... its like the article says, the mice were injected with THC before having the test, so they were pretty high and thus were having too much fun to care about finding the way out a maze... :jointsmile:

[thedeadone]

first the bastages get these unsuspecting participents, and get them really,
really loaded.Then the sonsabitches hide thier munchies from them.:hippy:

[denialisback]

That's a nice study.

Basically the more you smoke, the more resistant you become to forgetting stuff. Makes sense.

not quite, the study is saying that in the mice that were pre-treated there was a lower immunoreaction - i.e. the brain protects itself less..

Thus indicating long term exposure to THC decreases the neurological immuno ability of mice to supress the THC from affecting memory..

Quite an interesting study indeed. I would have expected the opposite too thcbongman :-)


Odd.

Peace,
denial

[thcbongman]

not quite, the study is saying that in the mice that were pre-treated there was a lower immunoreaction - i.e. the brain protects itself less..

Thus indicating long term exposure to THC decreases the neurological immuno ability of mice to supress the THC from affecting memory..

Quite an interesting study indeed. I would have expected the opposite too thcbongman :-)


Odd.

Peace,
denial

It's actually states the opposite.

Zif268 immunoreactivity was reduced in the CA3 of the hippocampus and in the prefrontal cortex only in non-pretreated animals, indicating that although tolerance to the effects of THC on neuronal activity was evident, cannabinoid-induced memory impairment in these animals persisted even after 24 days of exposure.

Which is why I don't understand the conclusion:

This study shows that after extended administration of THC, its spatial memory-impairing effects are resistant to tolerance.

[denialisback]

This study shows that after extended administration of THC, its spatial memory-impairing effects are resistant to tolerance.

It's saying that memory impaired effects via THC were observed to be resistant to the immunotolerance of the subjects of the experiment, in this case the prefrontal of mice.

i.e. THC shows resistance to immunotolerance in the trials even after 24 days of continuous exposure

Peace,
denial

[thcbongman]

Ah I see now.

Thanks for the clarification.

[denialisback]

Ah I see now.

Thanks for the clarification.

no worries it confused me too at first, was unexpected here too :thumbsup:

yes, very.. but then again it is still only mice..


You actually had me second guessing myself, lol, well done ;- ) that can only be a good thing!


Peace,
Denial

[Purple Banana]

Mmm... I'm eating cheese as I read this. Ever read that stupid book "Who Moved My Cheese?" it's supposed to apply as a metaphor to business and work in general, but it's so stupid!

Mice have completely different brains than us... Though the study has some applications to human brains, it's not 100% correct... I've been smoking for about 6 years, about 3 times a week, and my memory is just as sharp, if not sharper than it had been before I smoked!

I'm an outlier!

:stoned:

[beachguy in thongs]

You can be tolerant to the locomotor suppressant effects, of THC, but, you can't build tolerance to spatial memory and reversal learning. Cannabidiol makes up 40%* of the plant. I figured that it's the key ingredient to offset all the ill effects.

*-heard that, somewhere