You gotta keep in mind Diet affects the immune system on a large level as well. If you mix in a bad diet and heavy smoking I would say its possible. I am not an MD just an RN whoʻs in School for Bio Mechanical Engineering and Neurosciences.

But keep in mind that somewhere around 50% or regular Cannabis Smokers are also Cigarette Smokers as well and Cigarettes for fact lower the immune system.

But there are so many Variables involved itʻs hard to say certain.