Explain in more detail what you mean by "depersonalization"...feeling like outside looking in or more like derealization, things don't seem real? Are you certain its not a severe panic/anxiety attack? These type feeling are regularly asscociated with panic/anxiety as well as from suffering a severe trauma. In addition these feelings are also common with clinical depression, bipolar disorder and sleep deprivation. I have a severe sleep disorder as well as bipolar and I feel a little like that when I stay up a few nights. Check with a Doc but in the meantime try a dif strain or switch to/from Sativa/Indica. Have you been smoking long? Or have you went from Mexican mower deck weed to some banger? If you cant find answers then you may just have to quit burn in'.