My experience is that it seems to make prescription pain pills work even better so be careful with it when you first try it. Just use lightly till you understand how your body reacts. Just like taking a new prescription. Never take full strength at first. Take a half dosage till you see how your body reacts. I had a friend that died from taking blood pressure medication the first time because he didn't cut the dosage in half for a couple days. When I first started taking mine if I hadn't cut my dosage in half the same probably would have happened to me. Even with a half dosage it just knocked the shit out of me for 3 days.