No no. No anxiety.

Your trip has everything to do with the mindset and the setting you're in. If you're in a comfortable place and you're relaxed and happy, you'll have a good trip. If your girlfriend just dumped you and you're in a police precinct... probably not a good time to eat mushrooms.

Going into it with anxiety is going to ruin your trip, and you'll never want to do it again. And THAT would be a real goddamn shame.