when done correctly smell is not a problem
the most quiet fan i ever found was a panasonic whisperline inline fan rated for about 1.7 sones compared to can/vortex/fantec/ect are about 2.4 sones.
keep humidity low, your exhaust on the cab and a cool house should keep it low
its best to exhaust into another room or outside away from your grow room so you dont recycle warmer air.
get any strain you want, its up to you on what kinda high/medical values you want. if you pick a sativa learn to train it to keep a continuous canopy