I tried it in the '90's. Was expecting many years of pain to disappear and get loaded. My expectations were so high, I don't think anything happened! But, that is only one in many. I wasn't sure if the med was for your friend or his mother! Anyway, I think the doses of marinol may not be equivalent to what was being ingested with canabis. Besides, it taking so 'long to work'! If one cannot take it quickly, the pill is the only option. If it is a liquid form, there are ways to get it to work a little quicker and ask his/her /Dr. I am sure they will understand, or you can ask for a Dr. that does understand. So sorry to hear about this terribly illness, I lost a brother to it, good luck! :hippy: