Negative effects on metabolism?

[REALDope.]

Even though i made this thread i'm equally interested in this nut shrinkage and testosterone lowerage. Kinda freaked the shits outta me. And i thought i was the only horny stoner. haha. As i light my spliff i say this one goes out to the ladies... literally. imp:

[REALDope.]

And big thanks for providing the metabolism info!

[daihashi]

And big thanks for providing the metabolism info!

If you're currently a healthy male then you have nothing to worry about. Besides the effects are not permanent. Your testosterone will rise from the slight... slight drop that occurs through smoking as the THC leaves your body.

It's almost a negligible amount but I felt the need to voice it for anyone that already suffers from low testosterone. :thumbsup:

[REALDope.]

I'm a bboy (breakdancer) so I'm not buggin' a bout weight issues. Damn, mad props. You make that ask jeezes kat seem like a panzy. haha.
Peace. :rastasmoke:

[thcbongman]

Hold on there. Let's get this on the record correctly. Cannabis neither speeds nor slows the metabolic rate. Metabolic rate has nothing to do with what people smoke. It has to do with lots of other factors like muscle mass, caloric intake and expenditure, percentage of body fat, thyroid function, age, etc. Cannabis may affect caloric intake and appetite, and it certainly can affect cardiovascular function, but there's no evidence it has a direct effect one way or another on the basal or resting metabolic rates.

You can read some basic information about metabolic rate, which is what people mean when they say "metabolism," here:
Basal metabolic rate - Wikipedia, the free encyclopedia

I'll have to disagree. The act of smoking increases energy expenditure by stimulating the central nervous system. Therefore when you smoke cannabis, tobacco etc. you increase your metabolism. Not significant by any means, but temporarily for a little bit.

[daihashi]

I'll have to disagree. The act of smoking increases energy expenditure by stimulating the central nervous system. Therefore when you smoke cannabis, tobacco etc. you increase your metabolism. Not significant by any means, but temporarily for a little bit.

Taken from nova Institute: THC-Limits for Food PART 2 Section 5

5.1 Genetic material and cell metabolism
5.1.1 Cell studies

Cannabis smoke can exert mutagenic activity as a result of carcinogens (benzpyrenes, nitrosamines). This was established in the Ames test. THC itself is not mutagenic (WHO 1997). THC may reduce the synthesis of DNA, RNA and proteins and modulate the normal cell cycle. To obtain those effects, however, very high doses were required in cell studies. Hence, in a study by Tahir et al. (1992) microtubules and microfilaments in PC12 cells, which are vital for cell division, were disrupted in a dose-dependent manner following treatment with 10-30 mM (micromol) THC.
5.1.2 Studies with Cannabis users

Studies with Cannabis users did not establish any increase in chromosomal breaks (Matsuyama et al. 1976, Matsuyama and Fu 1981, Cruickshank 1976, Cohen 1976). Thus, after 72 days of marijuana smoking, no increase in chromosomal breaks was found when compared to the breakage rate preceding administration.

Joergensen et al. (1991) evaluated the genotoxicity of Cannabis smoking by application of the sister-chromatid exchange (SCE) test, a sensitive tool for the discovery of genotoxic agents. They compared 22 tobacco smokers and 22 persons that smoked tobacco and marijuana. The smoking of tobacco in itself enhanced the SCE level significantly by 18.5% compared to non-smoking controls. The addition of marijuana did not further affect this level. Based on this observation the authors concluded that Cannabis smoke could not be considered genotoxic.
5.1.3 Conclusion

THC in doses used by marijuana smokers is neither mutagenic nor carcinogenic and it does not affect cell metabolism, either. The NOAEL ranges above concentrations relevant for the human consumption situation.

5.3.4 Glucose metabolism

Fifty years ago, in a study with 62 volunteers, it was already demonstrated that Cannabis does not have any significant influence on glucose metabolism (Allentuck 1944). In another study, marijuana did not produce any relevant effects on glucose metabolism after 1 to 3 days of fasting. The glucose tolerance was not affected by marijuana (Permutt et al. 1976). However, in one other study a high THC dose (6 mg intravenous) influenced the glucose tolerance test scores in some probands (Hollister and Raven 1976).

Marijuana is actually a CNS depressant not stimulant.

[thcbongman]

Taken from nova Institute: THC-Limits for Food PART 2 Section 5




Marijuana is actually a CNS depressant not stimulant.

None the less, it stated that cannabis smoke can exert mutagenic activity as a result of carcinogens. I think that would qualify as the "act of smoking."

[daihashi]

None the less, it stated that cannabis smoke can exert mutagenic activity as a result of carcinogens. I think that would qualify as the "act of smoking."

Well I don't think I can argue that. No one would argue that. Smoking is exactly what they're talking about.

It's not the act of smoking persay but rather what is the uptake in your lungs. Meaning it's not the carcinogen uptake but rather THC vs Nicotine.

Nicotine is what increases energy expenditure as it is a stimulant. THC is a CNS depressant. This is why Marijuana can help many MS patients with nerve pain. Myelin becomes damaged in MS patients and chronic nerve pain can be developed. Because marijuana is a CNS depressant it numbs some of these exposed nerves helping to dull the pain.

Just to make sure I'm not off the mark about the Nicotine being the factor and not the actual act of smoking can you show me where you got this from:

"The act of smoking increases energy expenditure by stimulating the central nervous system."

Because if I use that in a google search every hit that matches seems to indicate they are referring to smoking of Tobacco or cigarettes; which has nicotine in it.

[thcbongman]

Ah, I see your point. I concede!

[DrSpoof]

i used to get the munches big time... was never overweight but had me a decent little belly. eventually i got over my need to eat when high and i find that it actually helps me control my hunger even when im not stoned.

after all, if you can will yourself not to eat when stoned, you can will yourself not to eat anytime lol. :rastasmoke:

DrSpiggity