Each strain affects you differently, there's weed that will stick you in one place for the duration of the high, then there's the weed that buzz's your mind.
Sativa does one of these, Indica does the other...although im not sure which does which.
Our minds are expanding when we smoke, I try filling the new mind space with some new knowledge, filling it with negatives like "im going crazy" is no good.
Perhaps a break is in store?
Then dr.dubbie suggests a good tokage session, in a really interesting environment.

As for the science part...well somebody else can help you there. :thumbsup: