Quote Originally Posted by chrons
Whoops, typo! I meant NO harmful effects.

Now the problems with SSRI drugs and marijuana is that marijuana lowers the serotonin levels in the brain, where Zolofts and most SSRI drugs have a chemical Sertraline which RAISES these levels in the brain, so when mixing Zoloft and Marijuana you are actually defeating the purpose of the Zoloft and the levels are fighting back and forth which can cause unbelievable mood swings and many other side affects.
No Sertraline is not found in all SSRI's. Sertraline is only found in Zoloft, that's its generic name. I have seen studies that go both ways, that marijuana lowers and marijuana raises serotonin levels in synaptic junctions. It seems that research may be pointing in the direction that at lower doses marijuana inhibits reuptake and in higher doses marijuana increases reuptake. If you prevent reuptake, then there is more serotonin at the junction. So in lower doses combined with an SSRI you are getting a synergistic effect. If you've been smoking while on the SSIR's in moderation, this may be why you are having the side effects because you are getting the synergistic effect from both.