Personal experience: No. But it's like "breaking the seal" when you're at the bar drinking... once you go the first time, you can't seem to stop.

Scientific explanation for potential high-killing (speculative):
-maybe the fat in the meal helps to metabolize/sequester the THC.
-I've heard that munchies result from weed-induced hypoglycemia. By remedying the hypoglycemia, you remedy the munchies (sometimes) and maybe lessen other effects as well?
-blood goes to the stomach for digestion (instead of to the brain, delivering the drug)

That's just a guess.
But personally, no, I don't think it matters much unless I'm just barely high to begin with. If I'm really baked it doesn't matter if I eat.
TheSmokingMonkey Reviewed by TheSmokingMonkey on . Does Eating Kill your High? When using marijuana in the smoked form, does eating cause you to loose your high? I've heard having taken too much (moreso in the eaten form) you can drink orange juice to help bring down the high. Just wondering if other foods did that in general or if it's a specific type of food. Rating: 5