I tried Chantix 2 years ago while I was smoking marijuana while I was going through chemo. The Chantix works very well for me and every other person that I PERSONALLY know. The reason why Chantix worked so well for me is because I was able to smoke while I took it. There was absolutely no will power involved. You just keep taking the pill and smoke and in a couple to few weeks you will not crave a gigarette and if you do smoke you will feel sick and it will taste really bad. But the marijuana high will be the same as it always was to you. The receptors CB1 and CB2 (cannabinoid receptors) are not affected by Chantix. The problem here I guess is that after you stop taking the pill and have quit smoking for a few months you are in danger of smoking cigarettes again because you ARE SMOKING!!! If you have another cigarette after months of not taking the pill, it will be a glorious return to your favorite brand of cigarettes. That is what happened to me. I am 1 week into starting it again and have learned my lesson. If you are going to smoke herb after Chantix, please resist the urge to smoke a cigarette again. Hope this helps