I've dealt with depression most my life, don't know why, but unless I'm high, I'm depressed. I take zoloft, and figure I would have done myself in if not for zoloft and occasional other stuff, mj works wonders when I've got it, the 2 together are the best for me. I think years of drug abuse really made my depression unfixable and am glad a pill a day keeps me steady, although my creativity has diminished alot. Mj helps there too. Theres this stuff called kratom that is legal and affordable, but after a while its addictive too, and very similar to opiate withdrawl, yuck! But it has helped me and many others get off opiates. If I miss a pill or 2 my wife tells me I need to take my zoloft, and load the bowl.