You can take them together if you want, hydrocodone is the synthetic version of codine, so the Tylenol 3 will prolly make the high better. I've found that if you take half of a regular tylenol with your hydro it will also intensify the effects because of the increased amount of acetaminophen.
Dope Chic Reviewed by Dope Chic on . Hydrocodone and Codeine Is it safe to take both hydrocodone (vicodin) and codeine (Tylenol 3) at the same time? Will it increase the effects at all to take them simultaneously? Rating: 5