So if I'm reading that right (I'm familiar with most but not all of the terminology in the report), the THC increasing dopamine levels has a sort of neuro-stimulatory effect to counter the cognitive inhibition and sedation? Although this would counter my previous theory that rapid dopamine reuptake is why cannabis exacerbates mine and some other people's pain.
Gandalf_The_Grey Reviewed by Gandalf_The_Grey on . Wondering about a particular effect of THC on the MU1 receptor-agonist mechanisms Last night I was in a significantly extra large amount pain so I took an extra dose of tramadol (a morphine receptor agonist), and now I've woken up at 3:00am with seratonin blasting through my brain. I'm unable to sleep because my brain is utterly excited, eccentric and wildly creative in thought, enthusiastic and possitive in outlook (as opposed to the usual as of late), and overal very clear thinking. I attribute this to the increase and reuptake-inhibition of seratonin triggered by tramadol Rating: 5