Last night I was in a significantly extra large amount pain so I took an extra dose of tramadol (a morphine receptor agonist), and now I've woken up at 3:00am with seratonin blasting through my brain. I'm unable to sleep because my brain is utterly excited, eccentric and wildly creative in thought, enthusiastic and possitive in outlook (as opposed to the usual as of late), and overal very clear thinking. I attribute this to the increase and reuptake-inhibition of seratonin triggered by tramadol and probably other MU receptor agonists.

What's interesting is that this possitive outcome only happens when I take the extra tramadol and smoke weed, after the effects of the THC have worn off. When I don't smoke any weed and double-up on the tramadol by itself, it just muddles up my brain, makes me tired and grouchy, and significantly hinderes my mental capacity.

So, does anybody have a theory as to why smoking weed with a morphine-receptor agonist would have such an opposite effect to the usual fatique, grouchiness, and mental hinderance?
Gandalf_The_Grey Reviewed by Gandalf_The_Grey on . Wondering about a particular effect of THC on the MU1 receptor-agonist mechanisms Last night I was in a significantly extra large amount pain so I took an extra dose of tramadol (a morphine receptor agonist), and now I've woken up at 3:00am with seratonin blasting through my brain. I'm unable to sleep because my brain is utterly excited, eccentric and wildly creative in thought, enthusiastic and possitive in outlook (as opposed to the usual as of late), and overal very clear thinking. I attribute this to the increase and reuptake-inhibition of seratonin triggered by tramadol Rating: 5