How old is your Nana, Steve? Is she diabetic, by any chance? Diabetics, particularly those who've had the disease for a long time, can develop diabetic neuropathy. That's basically nerve pain in the extremities. How's her circulation? Older patients frequently have a condition called peripheral vascular disease. That's plaque build up in the veins and arteries of their legs and arms, and it can cause significant pain. Whether she has one condition or the other (or both--diabetics are at much greater risk for PVD), smoking of any kind isn't indicated for that pain because it presents an extra challenge to her circulation, which is already compromised. Eating cannabis isn't a much better option because you really don't have an idea of the dosing or whether it might cause further vasoconstriction. If she has PVD, the drugs that would aid her most are calcium channel blockers or beta blockers to help her veins and arteries relax and dilate, medicines to help reduce plaque/cholesterol, pain relievers like morphine, which has a beneficial effect on circulation, and possibly an anti-coagulant medication.