Honestly I have never had any problems by using just two simple peices of software.

Microsoft Windows Defender
Avast! Antivirus

The two of those have caught everything that has ever come my way. Windows Defender is a nice little program that takes care of alot of your spyware and malware problems, and has a few other nice little additional perks in it as well.
imitator Reviewed by imitator on . Safe to delete IE? I have some spyware I can't get rid of. It doesn't affect Mozilla, but strictly IE. I don't use IE anyway, so it would deleting IE cause any conflicts with XP? Rating: 5